Controlled release formulations for oral administration
OwnerNarayanan Badri Vishwanathan, Rajeev S. Raghuvanshi +2inventors
InventorsNarayanan Badri Vishwanathan, Rajeev S. Raghuvanshi, Gour Mukherji, Ashok Rampal
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Abstract
A pharmaceutical composition in the form of an oral controlled release solid dosage form comprising an effective amount of drug, or its pharmaceutically acceptable salts. It also relates to a pharmaceutically composition that is suitable for once-a-day dosing regimen.
Claims61
A pharmaceutical composition for oral administration in humans for the controlled release of a drug or its pharmaceutically acceptable salts comprising a pharmaceutically effective amount of the drug in combination with a polymeric matrix comprising:
- a carboxyvinyl polymer, said carboxyvinyl polymer forming at least 30% by weight of the total polymeric content, and
- an alkaline compound.
A pharmaceutical composition for oral administration in humans for the controlled release of ofloxacin which releases more than 40% of ofloxacin in less than 4 hours and releases more than 60% of ofloxacin in less than 8 hours.
A pharmaceutical composition for oral administration in humans for the controlled release of ofloxacin which releases more than 40% of ofloxacin within about 2-4 hours and releases more than 60% of ofloxacin within about 4-8 hours.
A pharmaceutical composition for oral administration in humans for a once-a-day delivery system of a drug comprising:
- a pharmaceutically effective amount of the drug or its pharmaceutically acceptable salts;
- a polymeric matrix wherein at least one polymer is carboxyvinyl polymer, the carboxyvinyl polymer forming at least 30% by weight of the total polymeric content;
- cellulose ether;
- and
- an alkaline compound.
A pharmaceutical composition for oral administration in humans for the once-a-day delivery of ofloxacin which releases more than 40% of ofloxacin in less than 4 hours, releases more than 60% of ofloxacin in less than 8 hours and substantially all ofloxacin is released in about 10 hours.
A pharmaceutical composition for oral administration in humans for the once-a-day delivery of ofloxacin which releases more than 40% of ofloxacin within about 2-4 hours, releases more than 60% of ofloxacin within about 4-8 hours and substantially all ofloxacin is released within about 8-10 hours.
A once-a-day dosage form of ofloxacin which, when orally administered in humans under fed conditions, provides mean peak serum concentration, area under the serum concentration-time curve above minimum inhibiting concentrations and durations above minimum inhibitory serum concentrations, of not less than 70% when compared with respect to divided dose of an equivalent amount of conventional immediate release ofloxacin dosage form.
Dependencies are inferred from the claim text.