Oil-free pharmaceutical compositions containing cyclosporin A
AssigneeNovartis AG
InventorsArmin Meinzer, Barbara Haeberlin
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Abstract
The present invention provides a hard gelatine capsule containing a pharmaceutical composition comprising cyclosporin A in a mixture with a surfactant of HLB value at least 10, substantially free of any oil and when a hydrophilic phase is present, the hydrophilic phase being a polyethylene glycol and/or a lower alkanol provided that any lower alkanol present is present in less than 12% of the total weight of the composition absent the hard gelatine capsule.
Claims11
A hard gelatine capsule containing a pharmaceutical composition comprising cyclosporin A in a mixture with a surfactant of HLB value at least 10, substantially free of any oil and when a hydrophilic phase is present, the hydrophilic phase being a polyethylene glycol and/or a lower alkanol provided that any lower alkanol present is present in less than 12% of the total weight of the composition absent the hard gelatine capsule.
A hard gelatine capsule as defined in any preceding claim further comprising a thickening agent which is capable of dissolving in the stomach juices or water.
A hard gelatine capsule as defined in any preceding claim wherein cyclosporin is present in an amount of from 10 to 25% by weight based on the total weight of the composition absent the hard gelatine capsule.
A hard gelatine capsule as defined in any preceding claim comprising further excipients apart from the surfactant and as thickening agent in an amount of from 0.1 to 5% by weight based on the total weight of the composition absent the hard gelatine capsule.
A hard gelatine capsule as defined in any preceding claim wherein the hydrophilic phase is present.
Dependencies are inferred from the claim text.