Nucleosome-based anti-tumor compositions
AssigneeThe General Hospital Corporation, a Massachusetts corporation
InventorsVladimir P. Torchilin, Leonid Z. Iakoubov
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Abstract
A method of inhibiting neoplastic cell growth in a mammal by administering to the mammal nucleosomes that elicit the production of antinuclear autoantibodies sufficient to inhibit neoplastic cell growth.
Claims22
A method of treating an existing neoplastic cell growth in a mammal, said method comprising administering to the mammal an amount of nucleosomes effective to elicit in the mammal the production of sufficient antinuclear autoantibodies to inhibit neoplastic cell growth.
A method of inhibiting neoplastic cell growth in a mammal at risk for neoplastic cell growth, said method comprising administering to the mammal an amount of nucleosomes effective to elicit in the mammal the production of sufficient antinuclear autoantibodies to inhibit neoplastic cell growth.
A composition for eliciting the production of antinuclear autoantibodies in a mammal, said composition comprising substantially pure nucleosomes and a pharmaceutically acceptable carrier, diluent, or excipient.
Dependencies are inferred from the claim text.