Controlled heat induced rapid delivery of pharmaceuticals from skin depot
AssigneeZars, Inc.
InventorsJie Zhang, Wade Hull, Larry Rigby
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a method and system for delivering a drug into the systemic circulation. The method comprises establishing a drug depot in a patient's skin and/or sub-skin tissues by applying a transdermal drug delivery system on the patients skin, for a predetermined time so that a drug depot is formed in said user's skin and/or sub-skin tissues. A heating source is placed proximate to the skin area to rapidly release a bolus of the drug from the depot into the systemic circulation when there is a need to rapidly increase the drug's concentrations in the systemic circulation.
Claims30
A method of delivering a drug into a user's systemic circulation, comprising:
- establishing a drug depot in tissues under the user's skin surface by applying a transdermal drug delivery system on a user's skin;
- allowing said transdermal drug delivery system to be applied on said skin area without heating for at least a predetermined depot accumulation time so that a drug depot is formed in tissues under the surface of said skin area;
- and
- placing a heating source proximate to said skin area when there is a need to increase said drug's concentrations in the user's systemic circulation.
A method to provide baseline concentrations of an analgesic in a human being's systemic circulation and to rapidly deliver a bolus dose of said analgesic into said systemic circulation when said human being is suffering from an increased level of pain, comprising:
- applying a transdermal analgesic delivery system onto a skin area of a human being to establish baseline concentrations of said analgesic in said human being's blood;
- allowing said transdermal analgesic delivery system to be applied without heating for a time sufficient to allow the formation of an analgesic depot in tissues under the surface of said skin area of said human being;
- and
- placing a heating source proximate to said skin area when said human being suffers from increased level of pain.
A method of delivering a drug into the systemic circulation of a human being, comprising:
- establishing a drug depot in tissues under the surface of a skin area by applying a transdermal drug delivery system on the skin area of a human being and heating said skin area to a first pre-determined temperature range;
- allowing said transdermal drug delivery system to be applied while heating said skin area to said first temperature range for at least a predetermined minimum time period;
- and
- heating said skin area to a second temperature range, which is higher than said first temperature range, for a second pre-determined period of time.
A method to provide baseline concentrations of fentanyl in a human being's systemic circulation and to rapidly deliver a bolus dose of fentanyl into said systemic circulation when said human being is suffering from an increased level of pain, comprising:
- applying a transdermal fentanyl delivery system onto a skin area of a human being to establish baseline concentrations of fentanyl in said human being's blood;
- allowing said transdermal fentanyl delivery system to be applied without heating for a time sufficient to allow the formation of a fentanyl depot in tissues under the surface of said skin area of the said human being;
- and
- placing a heating source proximate to said skin area when said human being suffers from increased level of pain.
A method to provide baseline concentrations of sufentanil in a human being's systemic circulation and to rapidly deliver a bolus dose of sufentanil into said systemic circulation when said human being is suffering from an increased level of pain, comprising:
- applying a transdermal sufentanil delivery system onto a skin area of a human being to establish baseline concentrations of sufentanil in said human being's blood allowing said transdermal sufentanil delivery system to be applied without heating for a time sufficient to allow the formation of a sufentanil depot in tissues under the surface of said skin area of the said human being;
- and
- placing a heating source proximate to said skin area when said human being suffers from increased level of pain.
Dependencies are inferred from the claim text.