Drug eluting device for treating vascular diseases
OwnerLuc Levesque, Marcus F. Lawrence +2inventors
InventorsLuc Levesque, Marcus F. Lawrence, Bernard Bourguignon, Guy Leclerc
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Abstract
The present invention relates to a device and method for delivering locally therapeutic agents within adjacent tissues such as an arterial wall for treating vascular diseases. The device comprises i) an endovascular device, ii) an hydrophobic linker molecule containing a diazonium moiety electrodeposited onto the surface of the endovascular device, and iii) a lipophilic drug passively deposited on the linker molecule, said drug binding to the linker molecule through hydrophobic interactions for elution from the endovascular device over time. The present invention also relates to a method for preparing such device.
Claims40
A method for loading a drug onto an endovascular device, said method comprising the steps of :
- electrodepositing an hydrophobic molecule containing a diazonium moiety onto the surface of an endovascular device to obtain a functionalized surface of said device;
- and
- depositing passively a lipophilic drug onto said functionalized surface, said drug binding to the diazonium moiety of the molecule for slow elution into a tissue when said device is brought in contact with said tissue in vivo.
A drug-eluting endovascular device comprising:
- an endovascular device;
- an hydrophobic linker molecule containing a diazonium moiety electrodeposited onto the surface of the endovascular device;
- and
- a lipophilic drug passively deposited on the linker molecule, said drug binding to the linker molecule through hydrophobic interactions for elution from the endovascular device over time.
Dependencies are inferred from the claim text.