Compositions and methods for the therapy and diagnosis of ovarian cancer
AssigneeCorixa Corporation
InventorsPaul A. Algate, Darrick Carter
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Abstract
Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
Claims17
An isolated polynucleotide comprising a sequence selected from the group consisting of:
- (a) sequences provided in SEQ ID NO:462-477;
- (b) complements of the sequences provided in SEQ ID NO:462-477;
- (c) sequences consisting of at least 20 contiguous residues of a sequence provided in SEQ ID NO:462-477;
- (d) sequences that hybridize to a sequence provided in SEQ ID NO:462-477, under highly stringent conditions;
- (e) sequences having at least 75% identity to a sequence of SEQ ID NO:462-477;
- (f) sequences having at least 90% identity to a sequence of SEQ ID NO:462-477;
- and
- (g) degenerate variants of a sequence provided in SEQ ID NO:462-477.
An oligonucleotide that hybridizes to a sequence recited in SEQ ID NO:
- 462-477 under highly stringent conditions.
Dependencies are inferred from the claim text.