Protein-protein interactions in neurodegenerative diseases
AssigneeMyriad Genetics, Inc.
InventorsJean-Marc Roch, Paul L. Bartel, Karen Heichman
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Abstract
The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.
Claims50
An isolated protein complex comprising two proteins, the protein complex selected from the group consisting of:
- (a) a complex of CIB and MLK2;
- (b) a complex of a fragment of CIB and MLK2;
- (c) a complex CIB and a fragment of MLK2;
- and
- (d) a complex of a fragment of CIB and a fragment of MLK2.
A composition comprising:
- a first expression vector having a nucleic acid encoding CIB or a homologue or derivative or fragment thereof;
- and
- a second expression vector having a nucleic acid encoding MLK2, or a homologue or derivative or fragment thereof.
A host cell comprising:
- a first expression vector having a nucleic acid encoding a first protein which is CIB or a homologue or derivative or fragment thereof;
- and
- a second expression vector having a nucleic acid encoding a second protein which is MLK2, or a homologue or derivative or fragment thereof.
Dependencies are inferred from the claim text.