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US 2002/0119145 A1Published application
Tyrissamycin antibiotic
OwnerJingfang Cutrone, Lyndon M. Foster +6inventors
InventorsJingfang Cutrone, Lyndon M. Foster, Kimberly Krampitz, Stephen W. Mamber, Grace McClure, Todd C. Peterson, Lisa C. Rupar, Katie A. Thompson
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Abstract
A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Stretomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.
Claims3
A process for the preparation of tyrissamycin having the following characteristics:
- (a) a white amorphous powder;
- (b) soluble in chloroform, dimethylsulfoxide and methanol, and essentially insoluble in water:
- (c) exhibits an ultraviolet absorption spectrum when dissolved in methanol substantially as shown in FIG. 1;
- (d) exhibits an infrared absorption spectrum (KBr) substantially as shown in FIG. 2;
- (e) exhibits a proton magnetic resonance spectrum in CH3OD substantially as shown in FIG. 3;
- and
- (f) exhibits a 13C magnetic resonance spectrum in CH3OD substantially as shown in FIG. 4 which comprises cultivating a tyrissamycin-producing strain of Streptomyces lividans under submerged aerobic conditions in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen until a substantial amount of tyrissamycin is produced by said organism in said culture medium.
4 more elements
Dependencies are inferred from the claim text.