Biochemical methods that eliminate corneal scars, opacification and haze
AssigneeISTA Pharmaceuticals, Inc.
InventorHampar Karageozian
Life of this patent
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Abstract
The invention disclosed herein relates to biochemical methods for the elimination of corneal collagen fiber disorganization to improve vision. Disorganization of corneal collagen fibers is seen in corneal scars, corneal opacification and corneal haze. In addition, the invention relates to biochemical methods for the elimination of corneal collagen fiber disorganization resulting from accidental traumatic injury to the cornea and from refractive surgery for such as radial keratotomy (RK), photorefractive keratectomy (PRK), and laser in situ keratomileusis (LASIK) so as to improve visual acuity and quality of vision.
Claims29
The use of a corneal scar, opacity, and haze clearing enzyme for the manufacture of a medicament to eliminate corneal scar, opacity, and haze.
The use of claim 7, wherein said hyaluronidase is devoid of hyaluronidase MW fractions above 100,000, between 60,000-70,000, and below 40,000 using 10% SDS-PAGE.
A method for clearing corneal opacity comprising the step of administering a corneal scar, opacity, and haze clearing amount of an enzyme, whereby a corneal scar, opacity, and haze is eliminated.
Dependencies are inferred from the claim text.