Graft acceptance through manipulation of thymic regeneration
OwnerRichard Boydinventor
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Abstract
The present disclosure provides methods for inducing tolerance in a recipient to a mismatched graft of an organ, tissue and/or cells. By reactivating the recipient's thymus and providing hematopoietic stem cells from the donor, the previously “foreign” matter becomes recognized as “self” in the recipient and is not rejected. The patient's T cell population is depleted. In a preferred embodiment the hematopoietic stem cells are CD34+. The recipient's thymus is reactivated by disruption of sex steroid mediated signaling to the thymus. In a preferred embodiment this disruption is created by administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines or combinations thereof.
Claims18
A method for inducing tolerance in a patient to a graft from a mismatched donor comprising the steps of T cell ablation, reactivation of the thymus, and administration, from the graft donor to the patient, of cells selected from the group consisting of hematopoietic stem cells, epithelial stem cells, progenitor cells, and mixtures thereof.
A kit for the improvement of graft acceptance in a patient comprising an LHRH analog, a group of stem or progenitor cells from the donor of the graft,
Dependencies are inferred from the claim text.