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US 2002/0119106 A1Published application
Non-halogenated phenyl substituted phenols, antimicrobial compositions containing the same, and methods of using the same
OwnerDavid Scott Harper, Robert A. Coburn +3inventors
InventorsDavid Scott Harper, Robert A. Coburn, Constantine Georgiades, Andre Soshinsky, Marianne D. Huntley
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Abstract
A antimicrobial compound, compositions containing the same, and method of using the same for reducing the presence of microorganism on a substrate or in a fluid environment comprising an antimicrobial effective carrier and at least one antimicrobial compounds including non-halogenated phenyl substituted phenol compounds.
Claims75
A compound selected from the following formulas:
- 7
- wherein
- R1 and R2 are each independently selected from the group consisting of hydrogen, an alkyl group optionally substituted with a cycloalkyl group or an aryl group;
- an alkenyl group;
- an alkoxy group;
- a cycloalkenyl group;
- an aryl group;
- benzyl optionally substituted with an alkyl group;
- and a cycloalkyl group, wherein any one of which said groups can optionally be substituted with hydroxyl;
- and
- R3 is selected from the group consisting of hydrogen, a hydroxyl group, an alkyl group optionally substituted with hydroxyl, an aryl group, a benzyl group, a benzyloxy group, an alkoxy group, and a cycloalkyl group optionally substituted with hydroxyl;
- R4 is selected from the group consisting of hydrogen and an alkyl group optionally substituted with hydroxyl;
- with the proviso that,
- for compounds of Formula Ia, when R1 is a C1-8 n-alkyl group or a C3-6 cycloalkyl group, each being optionally partially or fully substituted with a C3-6 cycloalkyl group or a C1-7 side chain alkyl group, and R2 is hydrogen, then R3 is not selected from the group consisting of a C1-8 n-alkyl group and a C3-6 cycloalkyl group, each being optionally partially or fully substituted with a C3-6 cycloalkyl group or a C1-7 side chain alkyl group;
- for compounds of Formulas Ia through Ic, when R1 and R2 and R4 are each hydrogen, then R3 is not selected from the group consisting of hydrogen, a 4-alkyl group, or a 2-benzyloxy group;
- and
- for compounds of Formula Ic, wherein each of R1, R3 and R4 is hydrogen, then R2 is not selected from the group consisting of a methyl group, an ethyl group, or a tert-butyl group.
- for compounds of Formula Ic, wherein each of R1, and R4 is hydrogen, and R3 is a 2-hydroxyl, then R2 is not a tert-butyl group.
15 more elements
An antimicrobial composition comprising an antimicrobial acceptable carrier and an effective antimicrobial amount of at least one compound selected from the following formulas:
- 8
- wherein
- R1 and R2 are each independently selected from the group consisting of hydrogen, an alkyl group optionally substituted with a cycloalkyl group or an aryl group;
- an alkenyl group;
- an alkoxy group;
- a cycloalkenyl group;
- an aryl group;
- benzyl optionally substituted with an alkyl group;
- and a cycloalkyl group, wherein any one of which said groups can optionally be substituted with hydroxyl;
- and
- R3 is selected from the group consisting of hydrogen, a hydroxyl group, an alkyl group optionally substituted with hydroxyl, an aryl group, a benzyl group, a benzyloxy group, an alkoxy group, and a cycloalkyl group optionally substituted with hydroxyl;
- R4 is selected from the group consisting of hydrogen and an alkyl group optionally substituted with hydroxyl;
- with the proviso that,
- for compounds of Formula IIa, when R1 is a C1-8 n-alkyl group or a C3-6 cycloalkyl group, each being optionally partially or fully substituted with a C3-6 cycloalkyl group or a C1-7 side chain alkyl group, and R2 is hydrogen, then R3 is not selected from the group consisting of a C1-8 n-alkyl group and a C3-6 cycloalkyl group, each being optionally partially or fully substituted with a C3-6 cycloalkyl group or a C1-7 side chain alkyl group;
- and
- for compounds of Formulas IIa through IIc, when each of R1, R2 and R4 are each hydrogen, then R3 is not hydrogen.
13 more elements
An oral composition comprising an orally acceptable carrier and an effective antimicrobial amount of at least one compound selected from the following formulas:
- 9
- wherein
- R1 and R2 are each independently selected from the group consisting of hydrogen, an alkyl group optionally substituted with a cycloalkyl group or an aryl group;
- an alkenyl group;
- an alkoxy group;
- a cycloalkenyl group;
- an aryl group;
- benzyl optionally substituted with an alkyl group;
- and a cycloalkyl group, wherein any one of which said groups can optionally be substituted with hydroxyl;
- and
- R3 is selected from the group consisting of hydrogen, a hydroxyl group, an alkyl group optionally substituted with hydroxyl, an aryl group, a benzyl group, a benzyloxy group, an alkoxy group, and a cycloalkyl group optionally substituted with hydroxyl;
- R4 is selected from the group consisting of hydrogen and an alkyl group optionally substituted with hydroxyl;
- with the proviso that,
- for compounds of Formula IIa, when R1 is a C1-8 n-alkyl group or a C3-6 cycloalkyl group, each being optionally partially or fully substituted with a C3-6 cycloalkyl group or a C1-7 side chain alkyl group, and R2 is hydrogen, then R3 is not selected from the group consisting of a C1-8 n-alkyl group and a C3-6 cycloalkyl group, each being optionally partially or fully substituted with a C3-6 cycloalkyl group or a C1-7 side chain alkyl group;
- and
- for compounds of Formula IIa, when each of R1, R2 and R4 is a hydrogen, then R3 is not hydrogen.
13 more elements
Dependencies are inferred from the claim text.