Methods of imaging and targeting vasculature
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsNicholas W. Gale, George D. Yancopoulos
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Abstract
Methods for imaging and targeting tumor vasculature are provided. Specifically, the methods for imaging and targeting tumor vasculature relate to using ephrin-B2 to image developing tumor vasculature and to target therapeutic agents to developing tumor vasculature. Kits for imaging and targeting tumor vasculature are also provided. Also provided for are methods of delivering agents to vasculature.
Claims42
A method for imaging tumor vasculature in a mammal, comprising:
- a) administering to the mammal a composition which comprises a molecule capable of detecting ephrin-B2 nucleic acid or polypeptide coupled to an imaging agent;
- b) allowing the composition to accumulate at the tumor vasculature;
- and
- c) detecting the accumulated composition so as to image the tumor vasculature.
A method of causing tumor cell death by targeting tumor vasculature comprising administering to a mammal a composition which comprises a molecule capable of detecting ephrin-B2 nucleic acid or polypeptide coupled to an agent capable of causing tumor cell death.
A method of causing vascular endothelial cell death by targeting tumor vasculature comprising administering to a mammal a composition which comprises a molecule capable of detecting ephrin-B2 nucleic acid or polypeptide coupled to an agent capable of causing vascular endothelial cell death.
A kit for imaging tumor vasculature in a mammal comprising a composition which comprises a molecule capable of detecting ephrin-B2 nucleic acid or polypeptide coupled to an imaging agent.
A kit for targeting tumor vasculature in a mammal comprising a composition which comprises a molecule capable of detecting ephrin-B2 nucleic acid or polypeptide coupled to an agent capable of causing tumor cell death.
A kit for targeting tumor vasculature in a mammal comprising a composition which comprises a molecule capable of detecting ephrin-B2 nucleic acid or polypeptide coupled to an agent capable of causing vascular endothelial cell death.
A method of delivering an agent to the vasculature of a mammal comprising administering to the mammal a composition which comprises a molecule capable of localizing to a cell expressing ephrinB2 polypeptide, wherein the molecule is coupled to the agent.
40 The agent of claim 38 which is capable of preventing restenosis of a blood vessel.
Dependencies are inferred from the claim text.