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US 2002/0117453 A1Published application
Use of high density microparticles for removal of pathogens
AssigneeMiltenyi Biotec GmbH
InventorsDavid N. Cook, Rodney L. Monroy
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Abstract
Methods of using high-density microparticles to bind and remove pathogens from biological fluids are disclosed. Pathogens include prions, viruses, bacteria and protozoa.
Claims32
A method of removing at least one population of target pathogens from a biological fluid sample, comprising:
- (a) providing a plurality of high density microparticles having bound thereto a reactant which specifically binds to the target pathogen, and having a density sufficient to provide differential gravity settling of the target pathogen from the sample;
- (b) mixing a portion of the sample with the microparticles to bind the microparticles to the target pathogen;
- (c) settling the microparticles with the bound pathogen in the sample to produce a supernatant substantially free from the bound pathogen, where the settling is accomplished primarily by gravity;
- and
- (d) separating the microparticles bound to the pathogen from the supernatant.
2 more elements
A product, comprising:
- (a) a high density microparticle;
- and
- (b) a coating, said coating being a poly (glutamic acid, lysine, tyrosine) tri-amino acid polymer, wherein said glutamic acid, said lysine, and said tyrosine are present in said tri-amino acid polymer at a ratio of glutamic acid to lysine to tyrosine of 6:3:1.
Dependencies are inferred from the claim text.