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AssigneesInstitut Curie, Centre National De La Recherche Scientifique
InventorsDaniel Pinto, Sylvie Robine, Frederic Jaisser, Daniel Louvard
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The invention relates to regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of the intestine and uro-genital tracts. The invention also relates to recombinant constructs comprising said regulatory sequences, for the control of the targeted expression of determined nucleic acid sequences so-called (heterologeous sequences or also transgenes), in cells or tissues originating from the intestinal mucosa. A further object of the invention is to provide cells, tissues or organisms including animals, expressing said determined nucleic acid sequences in a targeted manner.
Nucleotide sequence derived from the 5′ sequence of the murine villin gene, having a size of 9 kb on an agarose gel, or a fragment thereof, comprising the nucleotide elements having a cis-regulatory activity that promotes the transcription of the murine villin gene.
Process for the preparation of a transgenic animal, especially a transgenic mice comprising the steps of:
Dependencies are inferred from the claim text.