Methods of and pharmaceutical compositions for improving implantation of embryos

A method of improving embryo implantation, the method comprising contacting a receptive uterus with an effective amount of heparanase and implanting the embryo in the receptive uterus.

A method of improving embryo implantation, the method comprising contacting a receptive uterus with an effective amount of heparanase, contacting an embryo with an effective amount of heparanase and implanting the embryo in the receptive uterus.

A method of improving IVF embryo implantation, the method comprising contacting an IVF embryo with an effective amount of heparanase and implanting the embryo in a receptive uterus.

A method of improving IVF embryo implantation, the method comprising contacting a receptive uterus with an effective amount of heparanase and implanting the IVF embryo in the receptive uterus.

A method of improving IVF embryo implantation, the method comprising contacting a receptive uterus with an effective amount of heparanase, contacting an IVF embryo with an effective amount of heparanase and implanting the IVF embryo in the receptive uterus.

An embryo coated with exogenous heparanase.

A pharmaceutical composition comprising, as an active ingredient, an effective amount of heparanase, the pharmaceutical composition is designed for intra-uterine application.

A pharmaceutical composition comprising, as an active ingredient, an effective amount of heparanase, the pharmaceutical composition is designed for application to an embryo in vitro.

An embryo growth composition comprising an effective amount of nutrients for embryonic growth and an effective amount of heparanase for assisting in embryo implantation.