Stabilizing diluent for polypeptides and antigens
AssigneeBiostar, Inc.
InventorsJeffrey W. Steaffens, Laura Panzarella
Life of this patent
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Abstract
Compositions for stabilizing polypeptides or antigens are described. These compositions are useful for stabilizing polypeptides or antigens stored in aqueous formulations. Such formulations can be used for various analytical or other methods.
Claims42
An aqueous reagent composition comprising a buffer, a blocking agent, a solubilizing agent, a salt, a chelating agent, a detergent, and a preservative at a final pH of 7.5 to 8.5, wherein said composition does not comprise N-dodecanoyl-N-methylglycine or decanoyl N-methylgluconamide.
A method of stabilizing an antigen or polypeptide in solution, comprising placing the antigen or polypeptide in an aqueous reagent comprising a buffer, a blocking agent, a solubilizing agent, a salt, a chelating agent, a detergent, and a preservative at a final pH of 7.5 to 8.5, wherein said reagent does not comprise N-dodecanoyl-N-methylglycine or decanoyl N-methylgluconamide.
A method of detecting a stabilized antigen or polypeptide in an aqueous solution, comprising:
- a) placing an antigen or polypeptide in an aqueous reagent comprising a buffer, a blocking agent, a solubilizing agent, a salt, a chelating agent, a detergent, and a preservative at a final pH of 7.5 to 8.5, wherein said reagent does not comprise N-dodecanoyl-N-methylglycine or decanoyl N-methylgluconamide;
- and
- b) detecting said antigen or polypeptide using an analytical method.
An aqueous reagent composition for stabilizing therein an antigen or a polypeptide comprising:
- a buffer, a blocking agent, a solubilizing agent, a salt, a chelating agent, a detergent, and a preservative at a final pH of 7.5 to 8.5, wherein said composition does not comprise N-dodecanoyl-N-methylglycine or decanoyl N-methylgluconamide.
Dependencies are inferred from the claim text.