Magnetic particles for diagnostic purposes
OwnerHeinz Gries, Wolfgang Mutzel +2inventors
InventorsHEINZ GRIES, WOLFGANG MUTZEL, CHRISTIAN ZURTH, HANNS-JOACHIM WEINMANN
Life of this patent
Estimating the term…
Abstract
Agents containing magnetic particles are suitable for use in enhancing images in diagnostic procedures, e.g., via x-ray, ultrasound or especially NMR. Preferred particles are based on metals, e.g., iron, cobalt or nickel, double metal oxides/hydroxides or complexes thereof.
Claims46
A pharmaceutical composition useful in diagnostic medical procedures comprising a pharmaceutically acceptable carrier and a physiologically compatible magnetic material in particulate form, with the proviso that the magnetic material is not magnetite-dextran, magnetite-human serum albumin or magnetite-oleic acid.
A magnetic complex of Fe2O3, or of a double metal-oxide/hydroxide
- of the formula mMO.nFe2O3, wherein M is a bivalent metal ion or a mixture of two bivalent metal ions,
- or of the formula nFeO.mM2O3, wherein M is a trivalent metal ion,
- and each of m and n independently is a number 1 to 6,
- with a water-soluble-mono-, di-, oligo- or polysaccharide, a protein or a carboxylic acid as complexing agent,
- with the proviso that the double metal-oxide/hydroxide is not magnetite when the complexing agent is human serum albumin, dextran or oleic acid.
A method of performing an NMR diagnosis comprising administering an NMR image enhancing agent to a patient in conjunction with an NMR measurement, wherein the agent comprises a physiologically compatible magnetic material in particulate form.
A method of performing an x-ray diagnosis comprising administering an x-ray image enhancing agent to a patient in conjunction with an x-ray measurement, wherein the agent comprises a physiologically compatible magnetic material in particulate form, with the proviso that the agent is not iron oxide-dextran.
A method of performing an ultrasound diagnosis comprising administering an ultrasound image enhancing agent to a patient in conjunction with an ultrasound measurement, wherein the agent comprises a physiologically compatible magnetic material in particulate form.
Dependencies are inferred from the claim text.