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US 2002/0058902 A1Published application
Tissue ablation by shear force for sampling biological fluids and delivering active agents
AssigneeLifeScan, Inc.
InventorsNikiforos Kollias, Ying Sun, Coston Anthony F.
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Abstract
The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating said membrane with a shear device; and utilizing a driving force to move said molecule through said perforated membrane.
Claims23
A method for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of:
- ablating said membrane with a shear device comprising a sheet containing at least one opening and a shear member, where said sheet is contacted with said membrane such that a portion of said membrane is forced through said opening and ablates said portion of said membrane exposed through said opening;
- and
- utilizing a driving force to move said molecule through said perforated membrane.
Dependencies are inferred from the claim text.