# US 2002/0058799 A1 · Novel pth

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- Number: US 2002/0058799 A1
- Document ID: US20020058799A1
- Status: Published application
- Kind: A1
- Application number: 09/847,209
- Filed: 2001-05-02
- Published: 2002-05-16
- Earliest claimed: 1998-05-18
- Inventors: Sanjoy Biswas; James Raymond Brown; Christine Debouck; Deborah Dee Jaworski; Elizabeth Jane Lawlor; Jeffrey Mooney; Lisa Kathleen Shilling; Min Wang; Richard Lloyd Warren; Magdalena Zalacain; Yi Yi Zhong; John Peter Throup; Karen Anne Ingraham; Alison Frances Chalker; David John Holmes; Christopher Michael Traini
- Web page: https://patentgrep.com/patent/US20020058799A1

## CPC

- C12N 9/18: Carboxylic ester hydrolases {(3.1.1)}
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.

## Claims

### Claim 1

An isolated polynucleotide segment, comprising a first polynucleotide sequence, wherein the first polynucleotide sequence encodes a polypeptide comprising SEQ ID NO:2.

### Claim 2 (depends on 1)

A vector comprising the isolated polynucleotide of claim 1.

### Claim 3 (depends on 2)

An isolated host cell comprising the vector of claim 2.

### Claim 4 (depends on 3)

A process for producing a polypeptide, comprising culturing the host cell of claim 3 under conditions sufficient for the production of the polypeptide, wherein the polypeptide is encoded by the first polynucleotide sequence.

### Claim 5

An isolated polynucleotide segment, comprising a first polynucleotide sequence, wherein the first polynucleotide sequence encodes a polypeptide consisting of SEQ ID NO:2.

### Claim 6 (depends on 5)

A vector comprising the isolated polynucleotide segment of claim 5.

### Claim 7 (depends on 6)

An isolated host cell comprising the vector of claim 6.

### Claim 8 (depends on 7)

A process for producing a polypeptide, comprising culturing the host cell of claim 7 under conditions sufficient for the production of the polypeptide, wherein the polypeptide is encoded by the first polynucleotide sequence.