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US 2002/0058784 A1Published application
Ureins derived from alpha, omega, -diamond acids and process for their preparation
AssigneeSolvay (Societe Anonyme)
InventorsRoland Callens, Georges Blondeel, Marc Anteunis, Frank Becu
Life of this patent
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Abstract
Ureins are obtained by reaction, in basic medium, between an Nω-(aryloxycarbonyl)diamino acid and a compound containing a free amino group. The chirality of the compounds is outstandingly well preserved.
Claims10
Process for the preparation of ureins derived from an α,ω-diamino acid according to which a compound containing a free amino group is reacted, in basic medium, with a diamino acid derivative containing an Nω-aryloxycarbonyl group.
Nω-Carboxyalkylcarbamoyl-α,ω-diamino acids of general formula
- 8
- in which A represents a bivalent group consisting of a linear carbon chain formed from 4 to 8 carbon atoms, which chain is optionally substituted by one or a number of groups chosen from C1-C3 alkyl groups and functional groups comprising at least one oxygen or sulphur atom such as a carboxyl, acyl, hydroxyl, alkoxy or mercapto group, and in which R3-NH represents an amino acid or a peptide.
Cyclic ureins of general formula
- 9
- in which A represents a bivalent group consisting of a linear carbon chain formed from 1 to 3 carbon atoms, which chain is optionally substituted by one or a number of groups chosen from C1-C3 alkyl groups and functional groups comprising at least one oxygen or sulphur atom such as a carboxyl, acyl, hydroxyl, alkoxy or mercapto group, with the exception of 2-oxoimidazolidinyl-4-carboxylic acid and (LD)-2-oxohexahydropyrimidinyl-4-carboxylic acid.
Peptides of general formula
- 10
- in which A is a bivalent group consisting of a linear carbon chain formed from 2 or 3 carbon atoms, which chain is optionally substituted by one or a number of groups chosen from C1-C3 alkyl groups and functional groups comprising at least one oxygen or sulphur atom such as a carboxyl, acyl, hydroxyl, alkoxy or mercapto group.
Dependencies are inferred from the claim text.