Ion channel modulating agents

An oxime derivative represented by the general formula

• 13
• or a pharmaceutically acceptable salt or an oxide or a hydrate thereof, wherein,
• X represents oxygen, sulphur, or an amino group, preferably an amino group of the formula NHR3;
• R1 represents hydrogen;
• an alkyl group;
• a cycloalkyl group;
• hydroxy;
• an alkoxy group;
• an acyl group;
• a phenyl or a benzyl group, which phenyl and benzyl groups may be substituted one or more times with substituents selected from halogen, —NO2, —CN, —CF3, alkyl, cycloalkyl, hydroxy, and alkoxy;
• a group of the formula —CH2CN;
• a group of the formula —CH2CO2R′, wherein R′ represents hydrogen or an alkyl group;
• a group of the formula —CH2CONRIVRV, wherein RIV and RV independently represents hydrogen or an alkyl group;
• or a group of the formula —CH2C(═NOH)NH2;
• R2 represents hydrogen, an alkyl group, a cycloalkyl group, a phenyl or a benzyl group, which phenyl and benzyl groups may be substituted one or more times with substituents selected from halogen, —NO2, —CN, —CF3, alkyl, cycloalkyl, hydroxy, and alkoxy;
• R3 represents hydrogen, an alkyl group, a cycloalkyl group, a phenyl or a benzyl group, which phenyl and benzyl groups may be substituted one or more times with substituents selected from halogen, —NO2, —CN, —CF3, alkyl, cycloalkyl, hydroxy, and alkoxy;
• and
• R4 and R5, independently of each another represents hydrogen;
• halogen;
• —NO2;
• —CN;
• —CF3;
• an alkyl group;
• an alkoxy group;
• a phenyl or a benzyl group, which phenyl and benzyl groups may be substituted one or more times with substituents selected from halogen, —NO2, —CN, —CF3, alkyl, cycloalkyl, hydroxy, and alkoxy, or a group of the formula —SO2NR″R′″, wherein R″ and R′″ independently of each another represents hydrogen or an alkyl group;
• or R4 and R5 together form an additional 4 to 7 membered fused ring, which fused ring may be aromatic or partially saturated, and which fused ring may optionally be substituted one or more times with substituents selected from the group consisting of halogen, —NO2, —CN, —CF3, and a group of the formula —SO2NR″R′″, wherein R″ and R′″ independently of each another represents hydrogen or an alkyl group.