Methods for treating seizure disorders by inhibiting MAPK pathway activation
OwnerJ. David Sweatt, Anne E. Andersoninventors
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Abstract
Excessive brain neuronal excitability, associated with a seizure disorder, can be correlated with increased mitogen-activated protein kinase (MAPK) activity in neurons. Such excessive excitability can be ameliorated by administering an effective amount of a compound, such as a MAPK phosphorylation or kinase activity inhibitor, that reduces the amount of MAPK activity in neurons of an individual suffering from a seizure disorder. Compounds that inhibit phosphorylation or kinase activity of upstream activators or downstream targets of the MAPK cascade also are useful in this context.
Claims21
A method of reducing or inhibiting excessive neuronal excitability in an individual resulting from an increased mitogen-activated protein kinase (MAPK) activity in neurons of the individual, comprising administering an effective amount of a compound that reduces the amount of MAPK activity in the neurons.
A method of reducing or inhibiting excessive neuronal excitability in an individual resulting from an increased mitogen-activated protein kinase (MAPK) activity in neurons of the individual, comprising administering an effective amount of a compound that inhibits phosphorylation or kinase activity of the MAPK cascade downstream of MAPK.
A method of reducing or inhibiting seizures in an individual suffering from a seizure disorder, resulting from increased mitogen-activated protein kinase (MAPK) activity, comprising administering an effective amount of a compound that inhibits phosphorylation of potassium channels.
Dependencies are inferred from the claim text.