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US 2002/0058670 A1Published application
Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration
AssigneeBioChem Pharma Inc.
InventorsTarek Mansour, Alex Cimpoia, Krzysztof Bednarski
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Abstract
The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about −10° C. 1 wherein R1 and L are as defined herein.
Claims23
A process for producing a β-nucleoside analogue compound of formula (III):
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- and salts thereof, wherein R1 is a hydroxyl protecting group;
- and R2 is a purine or pyrimidine base or an analogue or derivative thereof, the process comprising glycosylating said purine or pyrimidine base at a temperature below about −10° C., with an intermediate of formula (II):
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- wherein L is halogen.
2 more elements
Dependencies are inferred from the claim text.