Cyclipostins, process for their preparation and use thereof

A compound of formula I

• 11
• wherein
• R1 is
• (a) a carbon chain having 2 to 30 carbon atoms, which can be straight-chain or branched, saturated or unsaturated, carbo- or heterocyclic, and in which the carbon chain is optionally mono- or disubstituted by a radical selected from:
• (a)(1) —OH,
• (a)(2)═O,
• (a)(3) —O—C1-C6-alkyl, in which alkyl is linear or branched,
• (a)(4) —O—C2-C6-alkenyl, in which alkenyl is linear or branched,
• (a)(5) —C1-C6-alkyl, in which alkyl is linear or branched,
• (a)(6) -aryl,
• (a)(7) —C1-C6-alkylbenzene,
• (a)(8) -diphenyl,
• (a)(9) —NH—C1-C6-alkyl, in which alkyl is linear or branched,
• (a)(10) —NH—C2-C6-alkenyl, in which alkenyl is linear or branched,
• (a)(11) —NH2,
• (a)(12)═S,
• (a)(13) —S—C1-C6-alkyl, in which alkyl is linear or branched,
• (a)(14) —S—C2-C6-alkenyl, in which alkenyl is linear or branched, and
• (a)(15) halogen,
• in which the substituents (a)(1) to (a)(15) are optionally additionally substituted, or
• (b) -[-aryl-(CH2)n]m, wherein [-aryl-(CH2)n]m is unsubstituted, or mono- or disubstituted by a radical as described in (a)(1) to (a)(15), and n and m independently of one another are integers zero, 1, 2, or 3;
• R2 is
• C1-C6-alkyl, wherein alkyl is unsubstituted, or mono- or disubstituted by a radical as described in (a)(1) to (a)(15),
• C2-C6-alkenyl, wherein alkenyl is unsubstituted or mono- or disubstituted by a radical as described in (a)(1) to (a)(15), or
• C2-C6-alkynyl, wherein alkynyl is unsubstituted or mono- or disubstituted by a radical as described in (a)(1) to (a)(15);
• E is a phosphorus (P) or sulfur (S) atom;
• and
• X1, X2, and X3 are each selected independently from
• —O—,
• —NH—,
• —N═,
• —S—,
• —CH2—, and
• —CHR—;
• in any stereochemical form, or a mixture of any stereochemical forms in any ratio, or a physiologically tolerable salt or chemical equivalent thereof.