Purine L-nucleosides, analogs and uses thereof

A compound having a structure according to Formula I:

• 8
• wherein at least one of R1, R2, R3, R4, R5, R2′ and R3′ is OR′″, where R′″ is —C(O)Ra or a racemic, L, or D amino acid group —C(O)CHNH2Ra, and Ra is a substituted or unsubstituted alkyl;
• where remaining R1, R2, R3, R4, R5, R2′ and R3′ are independently selected from H, OH, NH2, F,e Cl, Br, I, N3, —CN, OR′, —NR′2, —SR′, —NHNH2, —NHOH, CHO, COOR′, CONR′2, alkyl, alkenyl, alkylnyl, aryl, aralkyl, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted aryl, substituted aralkyl, where the substituent is selected from F, Cl, Br, I, N3, —CN, —OR″, NO2, —NR″2, SR″, —NHNH2, —NHOH, COOR′, CONR″2, and where R′ and R″ are H, alkyl, alkenyl, alkynyl, aryl, aralkyl;
• W═O, S, CH2, Se;
• Z1, Z2, are independently selected from N, C, CH;
• Z3, Z4, Z5 are independently selected from the group consisting of —CR—, NR—, —O—, —S—, —Se —,—C═O, —C═S, —S═O, —CR═CR—, —CR═N—, —N═N—, where R is selected from the group consisting of H, F, Cl, Br, I, N3, —CN, —OR′, —NR′2, —SR′, —NHNH2, —NHOH, —NO2, CHO, COOR′, CONH2, —C(O)—NH2, —C(S)—NH2, —C(NH)—NH2, —C(NOH)—NH2, ═O, ═NH, ═NHOH, ═NR, alkyl, alkenyl, alkylnyl, aryl, aralkyl, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted aryl, substituted aralkyl, where the substituent is selected from H, —OH, NH2, F, Cl, Br, I, N3, —CN, —COOR″, —CONR″2, —OR″,—NR″2, —SR″, —NHNH2, —NHOH, —NO2, and R′, R″ are H, alkyl, alkenyl, alkynyl, aryl, aralkyl, acetyl, acyl, sulfonyl;
• The Chemical bond between Z3 and Z4 or Z4 and Z5 is selected from C—C, C═C, C—N, C═N, N—N, N═N, C—S, N—S;
• X and Y are independently selected from the group consisting of H, OH, NH2, F, Cl, Br, I, N3, —S—NH2, —S(O)—NH2, —S(O)NH2, —CN, —COOR′, —CONR′2, —OR′, —NR′2, —SR′,—NHNH2, —NHOH, alkyl, alkenyl, alkylnyl, aryl, aralkyl, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted aryl, substituted aralkyl, where the substituent is selected from F, Cl, Br, I, N3, —CN, —OR″, NO2, —NR″2, SR″, —NHNH2, —NHOH, and R′, R″, are H, alkyl, alkenyl, alkynyl, aryl, aralkyl.