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US 2002/0058634 A1Published application
Formulation of nitrogen mustard
AssigneeSuperGen, Inc.
InventorJoseph Rubinfeld
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AssigneeSuperGen, Inc.
InventorJoseph Rubinfeld
Estimating the term…
Compositions of matter comprising a substituted cyclodextrin and cytotoxic compound, especially cytotoxic drugs such as antibiotic, anti-fungal and anti-neoplastic, drugs are claimed. The compositions cause significantly less ulceration compared to the same formulation of cytotoxic compound without cyclodextrin compound when extravasated. The compositions may also cause less vascular irritation compared to the same formulation of cytotoxic compound without cyclodextrin when administered intravenously without extravasation. Compositions of matter comprising watersoluble cytotoxic agents, especially anticancer drugs and anti-ulceration effective or anti-irritatioin effective amounts of cyclodextrin compounds are also claimed. Methods for reducing the likelihood of ulceration and or irritation when administering the compositions according to the invention are also disclosed and claimed.
A composition of matter comprising an anti-ulceration effective amount of a substituted cyclodextrin compound and a cytotoxic drug.
A method for reducing the likelihood of ulceration or irritation in a subject in need of parenteral treatment with a cytotoxic compound that has the potential for causing ulceration when extravasated or irritation, comprising administering to such subjects a preparation comprising an aqueous solution of at least one cytotoxic compound that has the potential for causing ulceration when extravasated or irritation and an anti-ulceration effective or anti-irritation effective amount of a substituted cyclodextrin compound.
A composition of matter comprising an anti-ulceration effective or anti irritation effective amount of a hydroxypropyl substituted cyclodextrin compound having a degree of substitution of 5 to 10 and a cytotoxic drug.
A method for reducing ulceration or irritation in a subject in need of parenteral treatment with a cytotoxic compound such as an anti-cancer compound that has the potential for causing irritation or ulceration when extravasated, comprising administering to such subject a preparation comprising an aqueous solution of at least one cytotoxic compound such as an anti-cancer drug that has the potential for causing irritation or ulceration when extravasated and an anti-ulceration effective or anti-irritation effective amount of a hydroxypropyl substituted cyclodextrin compound having a degree of substitution of 5 to 10.
Dependencies are inferred from the claim text.