Compositions containing an antifungal and a phospholipid
AssigneeJanssen Pharmaceutica NV
InventorsROGER CAROLUS AUGUSTA EMBRECHTS, FRANK CHRISTOPHER ODDS, PIET RICHARD GUDULA DE DONCKER
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Abstract
The invention relates to compositions such as body and hair cleansing products, in particular shampoos, comprising one or more antifungals inhibiting fungal ergosterol biosynthesis as a first active ingredient, a synthetic, amphotheric phospholipid acting both as a second active ingredient and as a surface active agent, and art-known body or hair cleansing product ingredients as a carrier.
Claims14
A body or hair cleansing composition comprising
- (a-1) one or more antifungals inhibiting fungal ergosterol biosynthesis as a first active ingredient,
- (a-2) a synthetic amphotheric phospholipid as a second active ingredient, and
- (b) art-known body or hair cleansing product ingredients as a carrier.
A composition according to any one of the preceding claims wherein the first active ingredient is present in an amount ranging from about 0.1% to about 2% (w/w) and the second active ingredient is present in an amount ranging from about 0.04% to about 10% (w/w), the amount of the latter being expressed as weight of phospholipid.
A composition according to any one of the preceding claims formulated as a shampoo.
A process for preparing a shampoo formulation as defined in any one of the preceding claims comprising the steps of:
- (a) heating a solution of thickener and deionized water,
- (b) mixing the surfactants, the foaming agent and optionally the pearlizing agent with the solution of (a),
- (c) mixing the BHT with the solution of (b),
- (d) mixing the antifungal with the solution of (c),
- (e) dispersing the phospholipid in the mixture of (d),
- (f) allowing the suspension of (e) to cool somewhat and mixing therewith the preservative(s), the sodium chloride for thickening to the required viscosity, and optionally the conditioner, the fragrance(s) and colorant(s),
- (g) adding acid, base or buffer to the solution of (f) to yield a pH in the range of 4 to 10, and
- (h) adding deionized water to the solution of (g) to 100%.
Dependencies are inferred from the claim text.