Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures

A method of producing a pressure-sensitive transdermal drug delivery system suitable for a transdermal drug delivery system, comprising the steps of:

• (1) producing a blend of:
• (a) one or more solvent-based high shear resistant acrylic-based polymers having a shear resistance of greater than or equal to 50 hours at 8 pounds per square inch and 72° Fahrenheit and mixtures thereof;
• and
• (b) a therapeutically effective amount of one or more drugs, at least one of which is of low molecular weight and liquid at or about room temperatures, wherein the blend is in a solvent system;
• (2) forming the blend into a polymer matrix;
• and
• (3) drying the polymer matrix to remove the solvent system to form the transdermal drug delivery system, wherein the system forms a polymer matrix which has sufficient tack and shear for application to a human being.

A method of producing a pressure-sensitive transdermal drug delivery system suitable for a transdermal drug delivery system, comprising the steps of:

• (1) producing a blend of:
• (a) a pressure-sensitive adhesive polymer which consists of one or more solvent-based high shear resistant acrylic-based polymers having a shear resistance of greater than or equal to 50 hours at 4 pounds per square inch and 72° Fahrenheit and mixtures thereof;
• and
• (b) a therapeutically effective amount of one or more drugs, at least one of which is of low molecular weight and liquid at or about room temperatures, wherein the blend is in a solvent system;
• (2) forming the blend into a polymer matrix;
• and
• (3) drying the polymer matrix to remove the solvent system to form the transdermal drug delivery system, wherein the system forms a polymer matrix which has sufficient tack and shear for application to a human being.