Attenuated human rotavirus vaccine
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsYASUTAKA HOSHINO, ALBERT Z. KAPIKIAN, ROBERT M. CHANOCK
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Abstract
The present invention provides vaccine compositions of attenuated human rotavirus. More particularly, the attenuated human rotavirus is produced by cold passage and thus contains attenuating mutations which produce virus having a cold-adapted (ca) and temperature sensitive (ts) phenotype. The attenuated strains are used in methods for stimulating the immune system of an individual to induce protection against human rotavirus by administration of the ca attenuated rotavirus.
Claims39
A human rotavirus vaccine which comprises a live human rotavirus sufficiently attenuated by cold passage to reduce virulence while retaining the ability to induce a protective immune response in a human host.
A method for stimulating the immune system of an individual to induce protection against human rotavirus, which comprises:
- administering to the individual an immunologically sufficient amount of a composition which comprises a live human rotavirus sufficiently attenuated by cold passage to reduce virulence while retaining the ability to induce a protective immune response in a human host, in a physiologically acceptable carrier.
Dependencies are inferred from the claim text.