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US 2002/0058040 A1Published application
Stable immunogenic composition for frozen storage
OwnerStephen Grimes, Peter Blackburninventors
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Abstract
An injectable vaccine composition comprising an immunogenic conjugate in an emulsion containing advantageous oily vehicles is disclosed as suitable for frozen storage; moreover, a water-in-oil emulsion composition is found to enhance immunogenicity after storage at about −18° C.
Claims34
A stable immunogenic emulsion composition suitable for frozen storage comprising:
- an emulsion which comprises an aqueous phase containing an immunomimic epitope conjugated to an immunogenic protein carrier;
- and a pharmaceutically acceptable oily vehicle, which supports a stable emulsion during frozen storage.
The composition according to claim 2, wherein the immunomimic epitope is a non-peptide moiety.
An injectable immunogenic emulsion formulated for frozen storage comprising:
- (a) an aqueous phase comprising a hormone peptide or fragment thereof which is conjugated to an immunogenic protein carrier;
- and
- (b) an oily vehicle comprising a pharmaceutically acceptable oil or a mixture of pharmaceutically acceptable oils;
- wherein the emulsion is stable during frozen storage.
1 more element
Dependencies are inferred from the claim text.