Methods for treating FSH related conditions with GnRH antagonists
AssigneePraecis Pharmaceuticals, Inc.
InventorsMarc B. Garnick, Paul M. Martha JR., Christopher J. Molineaux, Alex DePaoli
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Abstract
Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the invention generally feature administering to a subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a subject, in an amount or in a formulation effective to reduce plasma FSH levels in the subject to a symptom alleviating level. In vitro fertilization and male contraceptive methods are also provided.
Claims59
A method for treating an FSH related condition in a subject, comprising administering to a subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a subject, in an amount or in a formulation effective to reduce plasma FSH levels in the subject to a symptom alleviating level, thereby treating an FSH related condition in the subject.
A method for treating prostatic intraepithelial neoplasia in a male subject, comprising administering to a male subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a male subject, in an amount or in a formulation effective to reduce plasma FSH levels in the male subject to a symptom alleviating level, thereby treating prostatic intraepithelial neoplasia in the male subject.
A method for treating vaginal bleeding in a female subject, comprising administering to a female subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a female subject, in an amount or in a formulation effective to reduce plasma FSH levels in the female subject to a symptom alleviating level, thereby treating vaginal bleeding in the female subject.
A method for contraception in a male subject comprising:
- administering to a male subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a male subject, in an amount or in a formulation effective to reduce plasma FSH levels in the male subject to a symptom alleviating level;
- and
- administering testosterone to the male subject in an amount or in a formulation effective to restore libido and potency in the male subject.
A method for modulating libido in a subject, comprising administering to a subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a subject, in an amount or in a formulation effective to reduce plasma FSH levels in the subject to a symptom alleviating level, thereby modulating libido in the subject.
A method for treating infertility in a female subject comprising:
- administering to a female subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a female subject, in an amount or in a formulation effective to reduce plasma FSH levels in the female subject to a symptom alleviating level;
- harvesting an ovum from the female subject before the effect of the GnRH antagonist has dissipated;
- combining the ovum with a spermatozoon in vitro, thereby fertilizing the ovum;
- and
- transferring the fertilized ovum into the uterus of the female subject, thereby treating infertility in the female subject.
A method for in vitro fertilization of an ovum comprising:
- administering to a female subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a female subject, in an amount or in a formulation effective to reduce plasma FSH levels in the female subject to a symptom alleviating level;
- harvesting an ovum from the female subject before the effect of the GnRH antagonist has dissipated;
- and
- combining the ovum with a spermatozoon in vitro, to thereby fertilize the ovum.
In a method for in vitro fertilization of an ovum comprising:
- administering a GnRH antagonist to a female subject in an amount or in a formulation effective to prevent the occurrence of a premature LH surge;
- harvesting an ovum from the female subject before the effect of the GnRH antagonist has dissipated;
- and
- combining the ovum with a spermatozoon in vitro, to thereby fertilize the ovum, the improvement comprising administering a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a female subject.
A method for reducing FSH levels in a subject comprising
- administering to the subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a subject, in an amount or in a formulation effective to reduce plasma FSH levels in the subject, thereby reducing FSH levels in the subject.
Dependencies are inferred from the claim text.