Combination therapy for treatment of autoimmune diseases using B cell depleting/immunoregulatory antibody combination
OwnerNabil Hannainventor
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Abstract
The present invention concerns treatment of autoimmune diseases with the combination of an immunoregulatory antibody, e.g. an anti-B7.1 or anti-B7.2 or anti-CD40L antibody and at least one B cell depleting antibody, such as CD19, CD20, CD22, CD23, or CD37, wherein such antibodies may be administered separately, or in combination, and in either order, over prolonged periods of time.
Claims41
A method of treating an autoimmune disease in a mammal comprising administering to the mammal the combination of a therapeutically effective amount of a immunoregulatory antibody selected from an anti-CD40L, anti-B7.1 (CD80), anti-B7.2(CD86), CD40 antibody and anti-CD4 antibody and a therapeutically effective amount of an antibody having B cell depleting activity, wherein said immunoregulatory antibody and said B cell depleting antibody may be administered separately or in combination, and in any order.
An article of manufacture comprising a container and one or several compositions contained therein, wherein at least one composition comprises a B cell depleting antibody, and at least another composition comprises an anti-CD40L or anti-B7.1 or anti-B7.2 antibody and further comprising a package insert instructing the user of the composition to treat a patient having or predisposed to an autoimmune disease.
A method of treating multiple sclerosis comprising administering the combination of an antibody to B7.1, B7.2 or CD40L and an anti-CD20 antibody having substantial B cell depleting activity, wherein said antibodies are administered separately or in combination, and in either order.
A method of treating ITP comprising administering the combination of an antibody to B7.1, B7.2 or CD40L and an anti-CD20 antibody having substantial B cell depleting activity, wherein said antibodies are administered separately or in combination, and in either order.
A method of treating lupus comprising administering the combination of an antibody to B7.1, B7.2 or CD40L and an anti-CD20 antibody having substantial B cell depleting activity, wherein said antibodies are administered separately or in combination, and in either order.
A method of treating diabetes comprising administering the combination of an antibody to B7.1, B7.2 or CD40L and an anti-CD20 antibody having substantial B cell depleting activity, wherein said antibodies are administered separately or in combination, and in either order.
A method of treating rheumatoid arthritis comprising administering the combination of an antibody to B7.1, B7.2 or CD40L and an anti-CD20 antibody having substantial B cell depleting activity, wherein said antibodies are administered separately or in combination, and in either order.
A method of treating psoriasis comprising administering the combination of an antibody to B7.1, B7.2 or CD40L and an anti-CD20 antibody having substantial B cell depleting activity, wherein said antibodies are administered separately or in combination, and in either order.
A method of treating thyroiditis comprising administering the combination of an antibody to B7.1, B7.2 or CD40L and an anti-CD20 antibody having substantial B cell depleting activity, wherein said antibodies are administered separately or in combination, and in either order.
A method of treating dermatitus comprising administering the combination of an antibody to B7.1, B7.2 or CD40L and an anti-CD20 antibody having substantial B cell depleting activity, wherein said antibodies are administered separately or in combination, and in either order.
A method of treating IBD comprising administering the combination of an antibody to B7.1, B7.2 or CD40L and an anti-CD20 antibody having substantial B cell depleting activity, wherein said antibodies are administered separately or in combination, and in either order.
Dependencies are inferred from the claim text.