C1 bacteriophage lytic system
AssigneeThe Rockefeller University
InventorsDaniel C. Nelson, Vincent A. Fischetti
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Abstract
The invention relates to the identification of C1 bacteriophage genes that express protein involved in the lysis of bacterial cells during the phage life cycle, lysin and holin. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in the treatment of an oral cavity bacterial infection.
Claims33
A homogeneously purified C1 bacteriophage lysin protein.
An isolated nucleic acid molecule encoding a C1 bacteriophage lysin protein.
A substantially purified C1 bacteriophage holin protein.
An isolated nucleic acid encoding a C1 bacteriophage holin gene.
The nucleic acid ofclaim 16, comprising a nucleotide sequence which is about 70% identical to the nucleotide sequence as set forth in SEQ ID NO:3.
An antibody which recognizes C1 holin.
An antibody which recognizes C1 lysin.
Dependencies are inferred from the claim text.