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US 2002/0058024 A1Published application
Modulators of the function of receptors of the TNF/NGF receptor family and other proteins
AssigneeYeda Research and Development Co. Ltd.
InventorsDavid Wallach, Andrei Kovalenko
Life of this patent
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Abstract
Proteins which are capable of modulating/mediating the function of RIP, their preparation and uses are provided.
Claims27
A molecule comprising a DNA sequence encoding a polypeptide which is capable of binding to RIP and modulating or mediating the intracellular activity of RIP, which polypeptide is:
- (a) a RIP-associated protein (RAP) encoded by said DNA sequence in a clone deposited with collection Nationale de Cultures de Microorganisme under the accession number I-2706;
- (b) a fragment of (a) which is capable of binding to RIP or inhibiting the NF-κB inducing effect of RIP;
- or
- (c) an analog of (a) or (b) which differs from the sequence of (a) or (b) by no more than 10 substitutions, deletions and/or insertions of amino acid residues and is capable of binding to RIP or inhibiting the NF-κB inducing effect of RIP.
1 more element
An isolated polypeptide which is capable of binding to RIP and modulating or mediating the intracellular activity of RIP, which polypeptide is:
- (a) a RIP-associated protein (RAP) encoded by a DNA sequence in a clone deposited with Collection Nationale de Cultures de Microorganismes under accession number I-2706;
- (b) a fragment of (a) which is capable of binding to RIP or inhibiting the NF-κB inducing effect of RIP;
- (c) an analog of (a) or (b) which differs from the sequence of (a) or (b) by no more than 10 substitutions, deletions and/or insertions of amino acid residues and is capable of binding to RIP or inhibiting the NF-κB inducing effect of RIP.
Dependencies are inferred from the claim text.