Isolated amphiphilic peptides derived from the cytoplasmic tail of viral envelope proteins
OwnerYanina Rozenberg, W. French Andersoninventors
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Abstract
An isolated peptide comprising an amino acid sequence derived from a viral envelope protein, wherein at least a portion of the amino acid sequence is located within the cytoplasmic tail or membrane-spanning region of a viral envelope protein. Such peptides are amphiphilic in nature, provide for the destabilization of membranes, and facilitate the entry of viral particles into cells and the efficient formation of viral particles. The peptides may, in another embodiment, be attached to the viral membrane, along with a targeting polypeptide, as part of an artificial viral envelope protein.
Claims46
An isolated peptide comprising a fragment of a viral envelope protein, wherein said peptide is free of the portion of the envelope protein N-terminal of the membrane-spanning region of the envelope protein, said peptide having a membrane-destabilizing activity.
Use of an amphiphilic compound having a membrane-destabilizing activity for the preparation of a viral vector.
A peptide selected from the group consisting of (SEQ ID NO:
- 2) and (SEQ ID NO:
- 3) and derivatives and analogues of (SEQ ID NO:
- 2) and (SEQ ID NO:
- 3) having at least one amino acid substitution of (SEQ ID NO:
- 2) and (SEQ ID NO:
- 3) that maintains the membrane-destabilizing activity of said peptide.
Dependencies are inferred from the claim text.