Pulmonary delivery in treating disorders of the central nervous system
AssigneeAdvanced Inhalation Research, Inc.
InventorsRaymond T. Bartus, Dwaine F. Emerich
Life of this patent
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Abstract
A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. The drug is administered at a dose which is at least about two-fold less than the dose required by oral administration. Particles that include the drug can be employed. Preferred particles have a tap density of less than about 0.4 g/cm3. In addition to the medicament, the particles can include other materials such as, for example, phospholipids, amino acids, combinations thereof and others.
Claims65
A method for treating a disorder of the central nervous system comprising administering to the respiratory tract of a patient in need of treatment a drug for treating said disorder, wherein the drug is administered in a dose that is at least about two times less than that required by oral administration and wherein delivery is to the pulmonary system.
A method for treating Parkinson's disease comprising administering to the respiratory tract of a patient in need of treatment or rescue therapy a drug for treating Parkinson's disease wherein the drug is administered in a dose that is at least about two times less than that required by oral administration and wherein delivery is to the pulmonary system.
A method for treating a disorder of the central nervous system comprising administering to the respiratory tract of a patient in need of treatment a drug for treating said disorder, wherein the drug is administered in a dose that is at least about two times less than that required by administration routes other than intravenous and wherein delivery is to the pulmonary system.
A method for treating a disorder of the central nervous system comprising administering to the respiratory tract of a patient in need of treatment or rescue therapy ketoprofen, wherein ketoprofen is administered in a dose that is at least about two times less than that required by oral administration and wherein delivery is to the pulmonary system.
A method for treating a disorder of the central nervous system comprising administering to the respiratory tract of a patient in need of rescue therapy a benzodiazepine drug, wherein the benzodiazepine drug is administered in a dose that is at least about two times less than that required by oral administration and wherein delivery is to the pulmonary system.
A method of treating a disorder of the central nervous system comprising:
- administering to the respiratory tract of a patient in need of rescue therapy particles comprising an effective amount of a benzodiazepine drug wherein the particles are delivered to the pulmonary system and the benzodiazepine drug is released in the blood stream of the patient and reaches its site of action within a time sufficiently short to provide said rescue therapy.
Dependencies are inferred from the claim text.