Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
OwnerJames C. Kennedy, Roy H. Pottier +3inventors
InventorsJames C. Kennedy, Roy H. Pottier, Robert L. Reid, Arnold Sac-Morales, Lewis L. Tomalty
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Abstract
Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor thereof is administered to the patient, or contacted to the exogenous cells, in an amount sufficient to induce synthesis fluorescence and/or photosensitizing concentrations of a protoporphyrin IX in the exogenous cells, followed by exposure of the exogenous cells to light of photoactivating wavelengths.
Claims10
A method for treating or detecting in a patient rapidly growing cells of exogenous origin that preferentially accumulate a photoactivatable porphyrin, comprising the steps of administering to said patient, or contacting said cells, with an effective amount of a precursor of protoporphyrin IX such that said exogenous cells accumulate therapeutic or detectable levels of said protoporphyrin IX, and thereafter exposing said cells to light capable of photoactivating said protoporphyrin IX.
A method for treating or detecting in a patient rapidly growing Protista cells that preferentially accumulate a photoactivatable porphyrin, comprising the steps of administering to said patient, or contacting said cells, with an effective amount of a precursor of protoporphyrin IX such that said Protista cells accumulate therapeutic or detectable levels of said protoporphyrin IX, and thereafter exposing said cells to light capable of photoactivating said protoporphyrin IX.
A method for treating or detecting in a patient rapidly growing parasite cells that preferentially accumulate a photactivatable porphyrin, comprising the steps of administering to said patient, or contacting said cells, with an effective amount of a precursor of protoporphyrin IX such that said parasite cells accumulate therapeutic or detectable levels of said protoporphyrin IX, and thereafter exposing said cells to light capable of photoactivating said protoporphyrin IX.
Dependencies are inferred from the claim text.