Back to results
US 2002/0055618 A1Published application
Methods and substances for preventing and treating autoimmune disease
AssigneeLoma Linda University
InventorsWILLIAM H.R. LANGRIDGE, TAKESHI ARAKAWA
Life of this patent
Estimating the term…
Abstract
A plant-based edible vaccine against autoimmune disease prepared by expressing a CTB-autoantigen chimeric gene construct in plant cells and transgenic plants is disclosed. DNA constructs, expression vectors comprising a nucleotide sequence that encodes a CTB-autoantigen chimeric gene, which are optimized for expression in plants, are described.
Claims30
A chimeric gene construct comprising:
- a plant promoter operatively associated with DNA comprising a CTB coding sequence and an autoantigen coding sequence:
A fusion protein comprising:
- a sufficient amount of amino acid sequence of a CTB protein such that the fusion protein is expressed and is capable of forming a pentameric structure as determined by GM1-ganglioside binding and an amino acid sequence of an autoantigen.
Dependencies are inferred from the claim text.