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AssigneeThe Regents of the University of California
InventorsPeter M. Elias, Walter M. Holleran
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The invention herein encompasses methods effective to stimulate epithelial cell proliferation and/or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition comprising one or more inhibitors of β-glucosidase activity or β-glucocerebrosidase activity. The composition of the method may alternatively comprise a glycosphingolipid, particularly glucocerebroside, or a combination of the above inhibitor(s) and a glycosphingolipid. The method is effective to enhance the cosmetic appearance of skin and promote healing of skin and mucous membranes damaged or deficient from aging, traumatic wounds, photo-aging and a variety of atrophic conditions. The method may be applied to cells in culture. Also included in the invention is a composition comprising one or more inhibitors of β-glucosidase and a glycosphingolipid useful to stimulate cell proliferation and enhance tissue moisturization and lubrication.
A method of stimulating epithelial proliferation and enhancing epithelial moisturization and lubrication in a subject, the method comprising administering to the subject an epithelial proliferation stimulating and epithelial moisturization and lubrication enhancing amount of a composition comprising at least one inhibitor of an enzyme having β-glucosidase activity.
A method of stimulating epithelial proliferation and enhancing epithelial moisturization and lubrication in a subject, the method comprising administering to the subject a tissue proliferation stimulating and epithelial moisturization and/or lubrication enhancing amount of a composition comprising a glycosphingolipid.
A method for stimulating tissue proliferation in a subject in need of or desiring tissue growth, the method comprising administering to the subject an amount effective to stimulate tissue proliferation of a composition comprising at least one inhibitor of an enzyme having β-glucosidase activity.
A method for stimulating tissue proliferation in a subject in need of or desiring tissue growth, the method comprising administering to the subject an amount effective to stimulate tissue proliferation of a composition comprising a glycosphingolipid.
A method for enhancing epithelial moisturization and lubrication in a subject, the method comprising administering to the subject an epithelial moisture and lubrication enhancing effective amount of a composition comprising at least one inhibitor of an enzyme having β-glucosidase activity.
A method for enhancing epithelial moisturization and lubrication in a subject, the method comprising administering is to the subject an epithelial moisture and lubrication enhancing effective amount of a composition comprising a glycosphingolipid.
A composition comprising at least one inhibitor of an enzyme having β-glucosidase activity and a glycosphingolipid.
An in vitro method of stimulating epithelial proliferation and enhancing epithelial moisturization and/or lubrication, the method comprising providing to the cell a cell proliferation stimulating and epithelial moisturization and lubrication enhancing amount of a composition comprising at least one inhibitor of an enzyme having β-glucosidase activity.
Dependencies are inferred from the claim text.