Methods for modulating the axonal outgrowth of central nervous system neurons
OwnerLarry I. Benowitzinventor
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Abstract
Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.
Claims44
A method for modulating axonal outgrowth of central nervous system neurons, the method comprising contacting the central nervous system neurons with a pharmaceutical composition consisting essentially of an effective amount of a purine nucleoside, or analog thereof, such that axonal outgrowth is modulated.
A method for stimulating the axonal outgrowth of central nervous system neurons following an injury, comprising administering to a subject a purine nucleoside, or analog thereof, such that axonal outgrowth is stimulated.
A pa nervous system disorder.
Dependencies are inferred from the claim text.