SOX-9 gene and protein and use in the regeneration of bone or cartilage
AssigneeThe University of Queensland
InventorsPeter Anthony Koopman, Peter Neville Goodfellow
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Abstract
This invention relates to an isolated DNA molecule encoding a Sox-9 gene which codes for the Sox-9 polypeptide. The human SOX-9 gene has been mapped to chromosome 17 in the same region as CMPD-1, the locus for Campomelic Dysplasia (CD). Sox-9 appears to have a role in mammalian skeletal development, and is used in the treatment of diseases involving bone or cartilage deficiency.
Claims10
An isolated DNA molecule comprising a DNA sequence selected from a group consisting of:
- (i) a sequence of nucleotides as shown in FIG. 1;
- (ii) a sequence complementary to the sequence according to (i);
- and
- (iii) a sequence having up to 21% variation from the sequences according to (i) or (ii) which sequence is capable of hybridising thereto under standard hybridisation conditions which codes for a polypeptide of the SOX-9 type.
An isolated DNA molecule comprising a DNA sequence selected from a group consisting of:
- (a) a sequence of nucleotides as shown in FIG. 8a;
- (b) a sequence complementary to the sequence according to (a);
- and
- (c) a sequence having up to 18% variation from the sequences according to (a) or (b) which sequence is capable of hybridising thereto under standard hybridisation conditions and which codes for a polypeptide of the SOX-9 type.
A recombinant protein comprising an amino acid sequence as shown in FIG. 1 as well as polypeptides of the SOX-9 type containing 93.5% - 100% identity to said sequence.
A recombinant protein comprising an amino acid sequence as shown in FIG. 8a as well as polypeptides containing 93.5% - 100% identity to said sequence.
Dependencies are inferred from the claim text.