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US 2002/0055124 A1Published application
Soluble support for organic synthesis
AssigneeThe Scripps Research Institute
InventorsKim D. Janda, Dennis J. Gravert
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AssigneeThe Scripps Research Institute
InventorsKim D. Janda, Dennis J. Gravert
Estimating the term…
Polymer supports for liquid-phase organic synthesis (LPOS) are employed in a process for transferring a chemical intermediate between immiscilbe solvents. These compounds are produced with an expanded range of solubility range in a variety of solvent systems. A sequence of normal and “living” free radical polymerizations are employed to generate a library of block copolymers possessing either block or graft architecture with initiators 100, 200 and 3-4 and a diverse set of vinyl monomers 5-9. Novel bifunctional initiators are employed that have functional groups that independently produce free radical polymerizations to produce the block copolymers. Preferred functional groups include diazene (—N═N—) and 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO) moieties tethered by ester or ether linkages.
A process for transferring a chemical intermediate from a first solvent to a second solvent, the first and second solvents being immiscible with one another, the process comprising the following steps:
A process for transferring a chemical intermediate from a second solvent to a first solvent, the first and second solvents being immiscible with one another, the process comprising the following steps:
A process for transferring a chemical intermediate from a first solvent to a second solvent and then from said second solvent to said first solvent, the first and second solvents being immiscible with one another, the process comprising the following steps:
A process for transferring a chemical intermediate into a first solvent, the process comprising the following steps:
A process for converting a first chemical intermediate into a second and third chemical intermediate, the process comprising the following steps:
A process for synthesizing a first conjugate including a platform and a first carrier, said first carrier being attached to said platform, the process comprising the following steps:
A process for synthesizing a second conjugate including a platform, a first carrier, and a second carrier, said first and second carriers being attached to said platform, the process comprising the following steps:
A composition comprising a solution including a first solvent and a first conjugate mixed as a solute therein, said first conjugate including a chemical intermediate, a platform, and a first carrier, said chemical intermediate and said first carrier being attached to said platform.
A composition comprising a solution including a second solvent and a second conjugate mixed as a solute therein, said second conjugate including a chemical intermediate, a platform, a first carrier and a second carrier, said chemical intermediate, said first carrier and said second carrier being attached to said platform.
A composition comprising a solution including a first solvent and a first conjugate mixed as a solute therein, said first conjugate including a chemical intermediate, a platform, and a plurality of a first carrier, said chemical intermediate and said plurality of the first carrier being attached to said platform.
A first conjugate represented by the following structure:
A second conjugate represented by the following structure:
An advanced intermediate represented by the following structure:
A first conjugate represented by one of the following structure:
A second conjugate represented by the following structure:
An advanced intermediate represented by the following structure:
A first conjugate represented by the following structure:
A second conjugate represented by the following structure:
A bifunctional initiator represented by the following structure:
A bifunctional initiator represented by the following structure:
A bifunctional initiator represented by the following structure:
A conjugate molecule represented by the following structure:
Dependencies are inferred from the claim text.