Prognostic method for prediction of progression of normal and hyperplastic mammary cells to carcinoma
AssigneeCalifornia Pacific Medical Center
InventorsGUOREN DENG, YOU LU, HELENE S. SMITH
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Abstract
The present invention encompasses methods for determining the likelihood that benign hyperplastic breast tissue or normal breast tissue adjacent to carcinoma tissue will become malignant. The methods comprise substantially isolating the tissue; and determining loss of heterozygosity (LOH) at chromosome 3p24 in the tissue. LOH at chromosome 3p24 is a prognostic indicator that the tissue may become malignant.
Claims4
A method for determining the likelihood of benign hyperplastic breast tissue or normal breast tissue adjacent to carcinoma tissue becoming malignant wherein the method comprises the steps of:
- substantially isolating the tissue;
- and determining the loss of heterozygosity (LOH) at chromosome 3p24 in the tissue, wherein LOH at chromosome 3p24 is a prognostic indicator that the tissue will become malignant.
Dependencies are inferred from the claim text.