Methods and systems for assessing biological materials using optical and spectroscopic detection techniques
AssigneeCytoscan Sciences LLC
InventorDaryl W. Hochman
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Abstract
Optical detection techniques for the assessment of the physiological state, health and/or viability of biological materials are provided. Biological materials which may be examined using such techniques include cells, tissues, organs and subcellular components. The inventive techniques may be employed in high throughput screening of potential diagnostic and/or therapeutic agents.
Claims16
A method for assessing the physiological condition of a sample biological population:
- maintaining at least one sample population of biological material in a viable condition;
- administering a contrast agent to the sample population;
- acquiring a test data set containing information relating to one or more optical properties of resolved spatial locations within the sample population following administration of the contrast agent;
- comparing the test data set to a comparison data set, wherein the comparison data set contains information relating to one or more optical properties of a predetermined sample population having a predetermined physiological condition;
- and
- assessing the response of the sample population to the administration of the contrast agent based on the comparison.
A database comprising data representing spatially and temporally resolved physiological response profiles of compounds and combinations of compounds having known effects on biological systems.
A method for screening a candidate compound for activity as a diagnostic or therapeutic agent, comprising:
- maintaining at least one sample population of biological material;
- introducing a candidate compound and a contrast agent to the sample population;
- acquiring and recording at least one test data set corresponding to one or more optical properties of the sample population following introduction of the candidate compound;
- comparing the test data set to a comparison data set, wherein the comparison data set corresponds to one or more optical properties of a predetermined sample population having a predetermined physiological state;
- and
- assessing the activity of the candidate compound as a diagnostic or therapeutic agent based on the comparison between the test data set and the comparison data set.
Dependencies are inferred from the claim text.