Polymeric coatings for controlled delivery of active agents
AssigneeSciMed Life Systems, Inc.
InventorsKalpana R. Kamath, James J. Barry, Sepideh H. Nott
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Abstract
Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical device further includes at least one composite layer of a bioactive agent and a polymer material and at least a barrier layer positioned over the composite layer and being of thickness adequate to provide a controlled release of the bioactive agent. The barrier layer being applied by a low energy plasma polymerization process which includes placing the device with the at least one composite layer in a plasma chamber and introducing at least one monomer gas.
Claims15
An implantable medical device comprising:
- a structure adapted for introduction into a patient, wherein the structure comprises a base material;
- at least one composite layer comprising at least one bioactive agent and polymer material applied to at least a portion of the outer surface of said base material;
- and
- at least one barrier layer positioned over the composite layer, said barrier layer having a thickness adequate to provide controlled release of the at least one bioactive agent;
- wherein said barrier layer is formed in situ by a low energy plasma polymerization process of a monomer gas.
A method for the localized delivery of a drug agent to a target location within a body, comprising the steps of:
- A) providing an implantable medical device which comprises a coated structure adapted for introduction into a patient, the structure comprising:
- (a) a base material;
- (b) at least one composite layer comprising at least one bioactive agent and a polymer material applied to at least a portion of the outer surface of said base material;
- B) forming at least one barrier layer comprising a polymer over the composite layer of said medical device, wherein said at least one barrier layer has a thickness adequate to provide a controlled release of the at least one bioactive agent, wherein said barrier layer is applied by a low energy plasma polymerization process which comprises:
- (i) placing said coated structure in a chamber;
- (ii) introducing at least one monomer gas into said chamber;
- and
- (iii) exposing the gas to a low energy source, whereby the monomer gas forms a barrier layer on the outer surface of the medical device;
- and
- C) delivering said implantable medical device to said target location.
Dependencies are inferred from the claim text.