Anti-inflammatory, tolerogenic and immunoinhibiting properties of carbohydrate binding-peptides
OwnerLouis D. Heerze, Glen D. Armstrong +1inventors
InventorsLouis D. Heerze, Glen D. Armstrong, Richard Smith
Life of this patent
Estimating the term…
Abstract
The present invention is directed to methods of suppressing inflammatory responses, inducing tolerance to an antigen, and suppressing cell adhesion, e.g., involved in metastasis, by the administration of lectin derived carbohydrate binding peptides or derivatives thereof, in particular, peptides capable of binding terminally linked α-sialic acid(2→6)βGal- and/or α-sialic acid(2→3)βGal-groups on structures or molecules comprising such groups. Pharmaceutical compositions containing such lectin derived carbohydrate binding peptides or derivatives thereof are also disclosed.
Claims29
A method of suppressing a inflammatory response in a mammal by the administration of an effective amount of at least one lectin derived carbohydrate binding peptide or derivative thereof capable of binding a terminally linked α-sialic acid(2→6)βGal- and/or α-sialic acid(2→3)βGal- groups on structures or molecules comprising such groups.
A method for modulating the induction of an immune response to an antigen in a mammal by administering the antigen in combination with an effective amount of at least one lectin derived carbohydrate binding peptide or derivative thereof capable of binding terminally linked α-sialic acid(2→6)βGal- and/or α-sialic acid(2→3)βGal- groups on structures or molecules comprising such groups.
A method for inducing, in a sensitized mammal, long term tolerance to an antigen by challenging said mammal with the antigen and followed by administering an effective amount at least one lectin derived carbohydrate binding peptide or derivative thereof capable of binding terminally linked α-sialic acid(2→6)βGal- and/or α-sialic acid(2→3)βGal- groups on structures or molecules comprising such groups.
A method for treating lung inflammation and/or lung injury in a mammal by administering an effective amount of one or more lectin derived carbohydrate binding peptides or derivative thereof capable of binding terminally linked α-sialic acid(2→6)βGal- and/or α-sialic acid(2→3)βGal- groups on structures or molecules comprising such groups.
A method for inhibiting metastasis of tumor cells in a mammal by administering an effective amount at least one lectin derived carbohydrate binding peptide or derivative thereof capable of binding terminally linked α-sialic acid(2→6)βGal- and/or α-sialic acid(2→3)βGal- groups on structures or molecules comprising such groups.
A method for inhibiting infection in mammalian hosts by bacterial/viral agents and/or their toxins which employ terminally linked α-sialic acid(2→6)βGal- and/or α-sialic acid(2→3)βGal- structures as the receptor site on a cell of the targeted mammalian host which method comprises administering to the mammal an effective amount at least one lectin derived carbohydrate binding peptide or derivative thereof capable of binding terminally linked α-sialic acid(2→6)βGal- and/or α-sialic acid(2→3)βGal- groups on structures or molecules comprising such groups.
Dependencies are inferred from the claim text.