Compositions and methods for enhancing antigen-specific immune response
AssigneeSisters of Providence in Oregon
InventorAndrew D. Weinberg
Life of this patent
Estimating the term…
Abstract
Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a composition comprising a purified OX-40 receptor binding agent and a pharmaceutically acceptable carrier, wherein said composition is administered to the mammal such that the OX-40 receptor binding agent is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen. Such compositions and methods can be used in immunization and cancer treatment.
Claims26
A method of enhancing the immune response of a mammal to an antigen, comprising administering to the mammal a composition comprising a purified OX-40 receptor binding agent and a pharmaceutically acceptable carrier, wherein said composition is administered to the mammal such that the OX-40 receptor binding agent is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen.
A method for stimulating the immune response of a mammal to a tumor cell in the mammal, comprising administering to the mammal a therapeutically effective dose of a purified OX-40 receptor binding agent.
A method for enhancing the immunogenicity of a cell, the method comprising introducing into the cell a nucleic acid molecule encoding an OX-40 receptor binding agent, such that the OX-40 receptor binding agent is expressed on the surface of the cell.
A method for stimulating the immune response of a mammal to a tumor in the mammal, comprising:
- (a) removing tumor cells from the mammal;
- (b) attenuating the removed tumor cells;
- (c) introducing into the attenuated tumor cells a nucleic acid molecule which encodes an OX-40 receptor binding agent such that the OX-40 receptor binding agent is expressed on the surface of the attenuated tumor cells;
- and
- (d) administering a therapeutically effective dose of a preparation of the attenuated tumor cells containing the nucleic acid molecule to the mammal.
A method for enhancing the immune response of a mammal to an antigen, comprising removing T-cells from the mammal, incubating the removed T-cells ex vivo with an OX-40 receptor binding agent, and returning the T-cells to the mammal.
A method of causing enhanced immune response against a tumor in a mammal, the method comprising increasing the amount of an OX-40 receptor binding agent at the tumor site.
A tumor cell transformed with a nucleic acid molecule encoding an OX-40 receptor binding agent, wherein the OX-40 receptor binding agent is expressed on the surface of the cell.
Dependencies are inferred from the claim text.