Peptide from soluble form of acetylcholinesterase, active as a calcium channel modulator
AssigneeSynaptica Limited
InventorsSUSAN ADELE GREENFIELD, DAVID JOHN TALBUTT VAUX
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Abstract
The acetylcholinesterase 14-mer peptide AEFHRWSSYMVHWK acts alone or in synergism with 2-amyloid to contribute to neuronal degeneration, e.g. in Parkinson's and Alzheimer's diseases, perhaps by exerting calcium channel opening activity. Antibodies and other compounds which inhibit the biological activity are useful for prophylaxis or treatment.
Claims12
A peptide containing at least 6 amino acid residues and having at least 70% homology with part or all of the sequence AEFHRWSSYMVHWK.
A peptide comprising or consisting of the sequence YMVH or MVHW or VHWK and having at least 70% homology with part or all of the sequence AEFHRWSSYMVHWK.
Dependencies are inferred from the claim text.