Nicotine mucosal spray
OwnerRichard L. Jonesinventor
Life of this patent
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Abstract
A composition for administration to the nasal mucosa of a subject comprises a solution of nicotine or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable solvent. The composition has a nicotine concentration less than 10 mg/ml. The composition used alone assists in reduction of the desire of a subject to smoke tobacco. It also reduces the nasal symptoms associated with administration of higher concentrations of nicotine to the nasal mucosa.
Claims20
A nicotine spray composition for administration to the nasal mucosa of a subject, said nicotine spray composition being in a form that can be sprayed as droplets of about 10 microns or more in size and comprising a solution of nicotine or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable solvent, said solution having a nicotine concentration less than 10 mg/ml.
A method that enables a subject to stop smoking and decreases the desire of a subject to smoke, said method comprising administering to the subject one source of an effective amount of! nicotine, said source being in the form of a nicotine nasal spray composition that can be administered to the nasal mucosa of the subject, the composition comprising droplets having a size of about 10 microns or more and a solution of nicotine or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable solvent, said solution having a nicotine concentration less than 10 mg/ml.
A method that enables a subject to step smoking and decreases the desire of a subject to smoke, said method comprising administering to the subject one source of an effective amount of nicotine, said source being in the form of a nicotine nasal spray composition that can be administered to the nasal mucosa of the subject, the composition comprising droplets of about 10 to 200 microns in diameter, and a solution of nicotine or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable solvent, said solution having a nicotine concentration of about 5 mg/ml to less than 10 mg/ml and a pH of about 6.5 to 7.5.
Dependencies are inferred from the claim text.