Loading patent…
OwnerErnest G. Schutt, David P. Evitts +3inventors
InventorsErnest G. Schutt, David P. Evitts, Rene Alta Kinner, Charles David Anderson, Jeffry G. Weers
Estimating the term…
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760−x) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents
A microbubble for the in vivo transport of physiological gases wherein the microbubble comprises at least one fluorocarbon gas and at least one modifier gas wherein the microbubble grows and shrinks to maintain osmotic equilibrium with the physiological gas saturation of the surrounding external medium.
A microbubble for in vivo delivery of physiological gases to an organism or tissues of an organism wherein the microbubble comprises at least one fluorocarbon gas and at least one modifier gas comprising oxygen wherein the microbubble grows or shrinks in diameter to maintain osmotic equilibrium with the surrounding external medium.
A microbubble composition for the in vivo transport of physiological gases wherein the microbubble comprises at least one fluorocarbon gas and at least one modifier gas wherein the microbubble first shrinks as a result of loss of the modifier gas to the surrounding medium and then grows as the microbubble gains osmotic equilibrium with the physiological gas saturation of the surrounding medium.
Dependencies are inferred from the claim text.